MOTS-c (Human)
Human MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded by mitochondrial 12S rRNA. It acts as a systemic metabolic regulator by activating the AMPK (cellular “metabolic master switch”) pathway, improving insulin sensitivity, enhancing fat oxidation, and delivering exercise-mimetic, anti-aging, and anti-inflammatory effects for metabolic and aging research.
Human MOTS-c is a synthetic 16-amino acid mitochondrial-derived peptide (MDP), encoded by the mitochondrial 12S rRNA gene, and a foundational research tool for metabolic biology and aging research. As one of the first characterized mitochondrial signaling peptides, it functions as a systemic endocrine regulator of cellular energy homeostasis:
Core Mechanism & Key Properties
- Inhibits the folate cycle and de novo purine synthesis, increasing intracellular AICAR levels to activate AMPK (the conserved cellular “metabolic master switch”)
- Translocates to the nucleus under metabolic stress to act as a mitochondrial-nuclear retrograde signal, regulating stress response and metabolic gene expression
- Improves peripheral insulin sensitivity, enhances fatty acid oxidation, and maintains glucose homeostasis
- Exerts antioxidant, anti-inflammatory, and mitochondrial biogenesis-promoting effects
- Naturally upregulated by exercise and fasting, delivering well-documented exercise-mimetic metabolic effects in preclinical models
Primary Research Applications
- Preclinical studies of insulin resistance, type 2 diabetes, and metabolic syndrome
- Exercise physiology and exercise-mimetic therapeutic research
- Aging biology and age-related metabolic decline investigations
- Mitochondrial signaling and inter-organelle retrograde communication studies
Manufactured to ≥98% purity, sterile-filtered, and lyophilized for long-term storage stability.
For laboratory research use only; not intended for human or veterinary administration.
Request Quote / COA
By submitting this form, you confirm the product is intended for laboratory research use only.
