PEPTIDE

MOTS-c (Human)

Human MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded by mitochondrial 12S rRNA. It acts as a systemic metabolic regulator by activating the AMPK (cellular “metabolic master switch”) pathway, metabolic signaling research, energy metabolism research, and delivering exercise-mimetic, anti-aging, and inflammation-pathway research observations for metabolic and aging research.

Human MOTS-c is a synthetic 16-amino acid mitochondrial-derived peptide (MDP), encoded by the mitochondrial 12S rRNA gene, and a foundational research tool for metabolic biology and aging research. As one of the first characterized mitochondrial signaling peptides, it functions as a systemic endocrine regulator of cellular energy homeostasis:

Core Mechanism & Key Properties

Inhibits the folate cycle and de novo purine synthesis, increasing intracellular AICAR levels to activate AMPK (the conserved cellular “metabolic master switch”)
Translocates to the nucleus under metabolic stress to act as a mitochondrial-nuclear retrograde signal, regulating stress response and metabolic gene expression
Improves peripheral insulin sensitivity, enhances fatty acid oxidation, and maintains glucose homeostasis
Exerts antioxidant, anti-inflammatory, and mitochondrial biogenesis-promoting effects
Naturally upregulated by exercise and fasting, delivering well-documented exercise-mimetic metabolic effects in preclinical models

Primary Research Applications

Preclinical studies of insulin resistance, type 2 diabetes, and metabolic syndrome
Exercise physiology and exercise-mimetic research research
Aging biology and age-related metabolic decline investigations
Mitochondrial signaling and inter-organelle retrograde communication studies

Manufactured to ≥99% purity, sterile-filtered, and lyophilized for long-term storage stability.

For laboratory research use only; not intended for human or veterinary administration.

Research use only: This material is supplied for laboratory research and documentation workflows only. It is not intended for human consumption, diagnostic use, therapeutic use, veterinary use or clinical application.

Hytan procurement and documentation support

For MOTS-c (Human), Hytan Peptides can support research-use sourcing review with available batch COA, vial labeling, product identity notes, storage documentation and wholesale quantity discussion. Product-specific CAS, sequence, molecular weight or method details should be confirmed against the current batch document before procurement decisions.

COA review: request batch-specific purity and identity references where available.
Wholesale planning: confirm vial strength, quantity, lead time, packing and destination requirements.
Compliance: research-use wording should remain clear in quote, invoice and receiving records.

Manufacturing Capability

Controlled production for consistent research peptide supply

Hytan Peptides supports wholesale research peptide orders with organized production workflow, clean handling, standardized filling, labeling and batch-level documentation. From material preparation to final review, each step is managed to support consistent appearance, traceable COA records and dependable supply coordination.

This production overview helps laboratories, distributors and qualified research buyers understand how Hytan Peptides approaches quality-focused peptide manufacturing, packaging and order readiness.