Ipamorelin
Ipamorelin is a selective pentapeptide growth hormone secretagogue (GHRP) that activates the GHS-R1a (ghrelin) receptor to stimulate physiological pulsatile growth hormone (GH) release. Unlike older GHRPs, it does not elevate cortisol, ACTH, prolactin, or appetite, making it the most selective GH-releasing peptide for metabolic and body composition research.
Ipamorelin is a synthetic pentapeptide growth hormone-releasing peptide (GHRP), developed as the most selective ghrelin receptor (GHS-R1a) agonist for targeted growth hormone (GH) regulation research:
Core Mechanism & Key Properties
- High-affinity, selective binding to GHS-R1a receptors on anterior pituitary somatotroph cells, stimulating physiological pulsatile GH release
- Unmatched selectivity: Unlike older generation GHRPs (GHRP-2, GHRP-6), it does not stimulate off-target secretion of ACTH, cortisol, prolactin, or ghrelin-mediated appetite, eliminating non-specific hormonal side effects
- Produces GH release kinetics that closely mimic natural endogenous GH secretion, preserving pituitary negative feedback regulation
- The gold-standard GHRP for synergistic research stacks with GHRH analogs (e.g., CJC-1295), amplifying GH secretion via complementary pituitary receptor pathways
Primary Research Applications
- Growth hormone secretion and pituitary endocrine function studies
- Body composition modulation (muscle anabolism, fat loss) research
- Exercise recovery and soft tissue regenerative medicine models
- Investigations of selective GH stimulation without off-target hormonal disruption
Manufactured to ≥98% purity, sterile-filtered, and lyophilized for long-term storage stability.
For laboratory research use only; not intended for human or veterinary administration.
Request Quote / COA
By submitting this form, you confirm the product is intended for laboratory research use only.
