NAD+
Nicotinamide Adenine Dinucleotide (NAD+) is an essential pyridine nucleotide cofactor that serves as the primary electron carrier in cellular redox reactions, supporting core energy metabolism pathways including glycolysis, the TCA cycle, and oxidative phosphorylation. Beyond energy transduction, it acts as a critical cosubstrate for sirtuins, PARPs, and other regulatory enzymes, mediating DNA repair, epigenetic regulation, cellular senescence, and aging processes.
Nicotinamide Adenine Dinucleotide (NAD+, oxidized form) is an essential, evolutionarily conserved pyridine nucleotide cofactor, foundational to all cellular energy metabolism and regulatory signaling research:
Core Biological Functions & Key Properties
- Primary electron carrier in cellular redox reactions: shuttles electrons between core metabolic pathways (glycolysis, TCA cycle, fatty acid oxidation, oxidative phosphorylation) to drive ATP production, cycling reversibly between its oxidized (NAD+) and reduced (NADH) forms
- Critical cosubstrate for key regulatory enzyme families:
- Sirtuins (NAD+-dependent deacetylases): mediate epigenetic regulation, metabolic homeostasis, and longevity signaling pathways
- PARPs (poly(ADP-ribose) polymerases): mediate DNA damage repair and maintenance of genomic stability
- CD38 and ADP-ribosyltransferases: mediate immune signaling and cellular calcium homeostasis
- Cellular NAD+ levels naturally decline with age, metabolic dysfunction, and oxidative stress, making it a core target for aging and metabolic disease research
Primary Research Applications
- Cellular energy metabolism and mitochondrial bioenergetics studies
- Aging biology and age-related functional decline research
- DNA damage repair and genomic stability investigations
- Sirtuin and PARP signaling pathway mechanistic studies
- Preclinical models of metabolic syndrome, neurodegeneration, and age-related degenerative disease
Manufactured to ≥98% purity, sterile-filtered, and lyophilized for long-term storage stability.
For laboratory research use only; not intended for human or veterinary administration.
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