Epithalon
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from pineal gland epithalamin. It is a foundational longevity research peptide that activates telomerase reverse transcriptase (TERT) to maintain telomere length, delay cellular senescence, and support circadian regulation, antioxidant defense, and immune function in aging biology studies.
Epithalon (also referred to as Epitalon) is a synthetic 4-amino acid tetrapeptide (sequence: Ala-Glu-Asp-Gly), corresponding to the active domain of the pineal gland-derived polypeptide epithalamin, developed and extensively studied for gerontology and longevity research:
Core Mechanism & Key Properties
- Activates telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase enzyme, to extend and maintain telomere length (the protective nucleotide caps at chromosome ends that shorten with each cell division, driving replicative cellular senescence)
- Penetrates cell and nuclear membranes to act as an epigenetic regulator, modifying chromatin structure and modulating expression of age-related regulatory genes
- Regulates pineal melatonin synthesis to normalize circadian rhythm homeostasis
- Exerts antioxidant, DNA repair-enhancing, and immunomodulatory effects to mitigate age-related cellular damage and functional decline
Primary Research Applications
- Longevity and gerontology research (telomere biology, cellular senescence, and age-related degenerative processes)
- Circadian rhythm and pineal gland function studies
- DNA damage repair and oxidative stress response research
- Immunosenescence and age-related immune decline investigations
Manufactured to ≥98% purity, sterile-filtered, and lyophilized for long-term storage stability.
For laboratory research use only; not intended for human or veterinary administration.
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