IGF-1 LR3 | Long R3 Insulin-Like Growth Factor 1 Research Peptide, Lyophilized Powder ≥98% HPLC Purity
Full Description Body
IGF-1 LR3, short for Long Arginine 3 Insulin-Like Growth Factor 1, is a fully synthetic 83-amino-acid peptide analog modified from native human IGF-1, exclusively produced for preclinical laboratory research at Hytan Peptides. Two core structural modifications set IGF-1 LR3 apart from natural IGF-1: a 13-amino-acid N-terminal extension and arginine substitution at position 3, which drastically reduce its binding affinity to IGF-binding proteins (IGFBPs).
Native IGF-1 is rapidly sequestered and inactivated by IGFBPs within minutes in lab test systems. In contrast, IGF-1 LR3 evades IGFBP capture efficiently, extending its biologically active half-life to 20–30 hours, delivering sustained receptor activation for consistent, repeatable experimental data. This unique property makes it the preferred analog for long-term cell culture and pathway research.
This lyophilized IGF-1 LR3 powder undergoes strict HPLC and mass spectrometry testing to guarantee minimum 98% peptide purity per batch. Every vial is sterile-filtered, vacuum-dried, and packed under low-temperature protection to preserve molecular stability during global cold-chain shipping. Complete Certificate of Analysis (COA) including purity reports, molecular weight verification and endotoxin test results is provided with each order for lab record-keeping.
In laboratory research environments, IGF-1 LR3 acts as a high-affinity agonist for IGF-1R tyrosine kinase receptors widely expressed on muscle, bone, cartilage, nerve and adipose cells. Upon receptor binding, it activates two core downstream signaling cascades: the PI3K/Akt/mTOR pathway regulating protein synthesis, cell survival and metabolic balance, and the MAPK/ERK pathway controlling cell proliferation and tissue differentiation.
Common research applications of IGF-1 LR3 include comparative IGF analog studies, skeletal muscle cell proliferation assays, bone and cartilage regeneration research, fat metabolism signaling analysis, satellite cell growth experiments, and long-term in-vitro cell culture models. Researchers often pair this peptide with supporting reagents including BAC Water and Acetic Acid Water for standardized reconstitution and long-term peptide storage.
Storage & Reconstitution Guidance
Unopened lyophilized IGF-1 LR3 vials should be stored at -20°C or lower, protected from direct light and moisture for maximum shelf life. After reconstitution with sterile peptide solvents, the prepared solution can be refrigerated at 2–8°C for short-term use or aliquoted and frozen at -20°C to avoid repeated freeze-thaw cycles that degrade peptide activity.
Disclaimer
All IGF-1 LR3 peptide products sold by Hytan Peptides are strictly manufactured and distributed for laboratory analytical and scientific research use only. This item is not approved for human injection, oral consumption, clinical therapy, veterinary treatment or cosmetic application. No statements on this page have been evaluated by the FDA or any global health regulatory authority.
For laboratory research use only; not intended for human or veterinary administration.
Research use only: This material is supplied for laboratory research and documentation workflows only. It is not intended for human consumption, diagnostic use, therapeutic use, veterinary use or clinical application.
Hytan procurement and documentation support
For IGF-LR3, Hytan Peptides can support research-use sourcing review with available batch COA, vial labeling, product identity notes, storage documentation and wholesale quantity discussion. Product-specific CAS, sequence, molecular weight or method details should be confirmed against the current batch document before procurement decisions.
- COA review: request batch-specific purity and identity references where available.
- Wholesale planning: confirm vial strength, quantity, lead time, packing and destination requirements.
- Compliance: research-use wording should remain clear in quote, invoice and receiving records.
Manufacturing Capability
Controlled production for consistent research peptide supply
Hytan Peptides supports wholesale research peptide orders with organized production workflow, clean handling, standardized filling, labeling and batch-level documentation. From material preparation to final review, each step is managed to support consistent appearance, traceable COA records and dependable supply coordination.
This production overview helps laboratories, distributors and qualified research buyers understand how Hytan Peptides approaches quality-focused peptide manufacturing, packaging and order readiness.
