KPV
KPV (Lysine-Proline-Valine) is a small tripeptide derived from the C-terminal of α-melanocyte-stimulating hormone (α-MSH). It delivers potent, targeted anti-inflammatory effects independent of melanocortin receptor binding, modulating intracellular inflammatory pathways (e.g., NF-κB) to support gut mucosal repair, skin healing, and immune regulation without the melanin-stimulating side effects of full-length α-MSH.
KPV (Lysine-Proline-Valine) is a synthetic tripeptide corresponding to the C-terminal bioactive fragment of α-melanocyte-stimulating hormone (α-MSH), optimized for targeted anti-inflammatory research:
Core Mechanism & Defining Properties
- Delivers potent anti-inflammatory effects via melanocortin receptor-independent modulation of intracellular inflammatory signaling pathways (including NF-κB and MAPK cascades)
- Eliminates the melanin-stimulating (pigment-inducing) side effects of full-length α-MSH, retaining only the parent hormone’s anti-inflammatory and immune-regulating activity
- Exhibits excellent cell and tissue penetration, enabling targeted action in gut mucosa, skin, and other inflamed tissues
- Supports resolution of inflammation without broad immune suppression, preserving normal host defense function
Primary Research Applications
- Inflammatory bowel disease and gut mucosal repair research
- Dermatological inflammation and wound healing studies
- Chronic inflammation and immune regulation models
- Investigations of targeted anti-inflammatory therapy without melanogenic side effects
Manufactured to ≥98% purity, sterile-filtered, and lyophilized for long-term stability.
For laboratory research use only; not intended for human or veterinary administration.
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