PEPTIDE

Semax

Semax is a synthetic heptapeptide analog of ACTH(4-10), developed by the Russian Academy of Sciences. It is a nootropic and neuroprotective peptide that upregulates BDNF and NGF in the hippocampus and prefrontal cortex, enhancing synaptic plasticity, memory, cognitive function, and neuroprotection, with well-documented use in stroke recovery and cognitive impairment research.

Semax is a synthetic heptapeptide (sequence: Met-Glu-His-Phe-Pro-Gly-Pro) analog of the cognitively active ACTH(4-10) fragment, extended with a C-terminal Pro-Gly-Pro motif for enhanced metabolic stability. Developed and clinically used in Russia for over 30 years, it is a gold-standard research tool for cognitive neuroscience and neuroprotection studies:

Core Mechanism & Defining Properties

Upregulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression by 2-5 fold in the hippocampus and prefrontal cortex, driving synaptic plasticity, dendritic spine formation, and neuronal survival
Modulates dopaminergic and serotonergic neurotransmission to improve focus, mood stability, and executive function
Exerts potent neuroprotective effects: reduces oxidative stress, inhibits excitotoxicity, and supports neuronal recovery after ischemic or traumatic injury
Clinically approved in Russia for stroke recovery, traumatic brain injury, optic nerve disease, and cognitive impairment

Primary Research Applications

Cognitive neuroscience: learning, memory, and synaptic plasticity research
Neuroprotection: stroke, traumatic brain injury, and neurodegenerative disease models
Neurotrophic factor signaling and BDNF pathway regulation studies
Mood regulation and cognitive enhancement preclinical research

Manufactured to ≥98% purity, sterile-filtered, and lyophilized for long-term storage stability.

For laboratory research use only; not intended for human or veterinary administration outside of approved clinical protocols.

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