TB500
TB-500 is a synthetic peptide corresponding to the active domain of human Thymosin Beta-4 (Tβ4). It regulates actin cytoskeletal dynamics to promote cell migration, angiogenesis, multi-tissue repair, and anti-inflammatory effects, making it a core research tool for wound healing and regenerative biology studies.
TB-500 is a metabolically stable synthetic peptide matching the conserved active domain of human Thymosin Beta-4 (Tβ4), one of the most abundant intracellular regulatory peptides in mammalian tissue. Optimized for regenerative research, it retains the core biological activity of full-length Tβ4:
Core Mechanism & Key Properties
- High-affinity binding to monomeric G-actin (globular actin), sequestering it to dynamically regulate cytoskeletal polymerization: this enables directed cell migration, cellular shape change, and coordinated tissue remodeling at injury sites
- Stimulates VEGF-mediated angiogenesis to form new microvessels, delivering nutrients and oxygen to regenerating tissue
- Modulates pro-inflammatory cytokine signaling to reduce excessive, damaging inflammation at injury sites
- Supports stem cell differentiation and cell proliferation to accelerate functional tissue regeneration
Primary Research Applications
- Preclinical studies of soft tissue repair (muscle, tendon, ligament, and connective tissue)
- Cutaneous wound healing and post-surgical recovery models
- Cardiovascular and dermal angiogenesis research
- Anti-inflammatory and chronic tissue remodeling studies
Manufactured to ≥98% purity, sterile-filtered, and lyophilized for long-term storage stability.
For laboratory research use only; not intended for human or veterinary administration.
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