PT141
PT-141 (Bremelanotide) is a cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH), acting as a central melanocortin (MC3/MC4) receptor agonist. FDA-approved (as Vyleesi) for hypoactive sexual desire disorder (HSDD) in premenopausal women, it acts directly on brain neural circuits to stimulate sexual desire and arousal, operating via a distinct central mechanism rather than peripheral vasodilation.
PT-141 (generic name: Bremelanotide) is a synthetic cyclic heptapeptide analog of α-MSH, and a centrally acting melanocortin receptor agonist, with FDA-approved clinical status for sexual dysfunction indications:
Core Mechanism & Defining Properties
- Non-selective melanocortin receptor agonist with highest affinity for MC4R and MC3R, which are highly expressed in hypothalamic and limbic brain regions governing sexual behavior and reward processing
- Unique mechanism: Unlike peripheral PDE5 inhibitors (sildenafil, tadalafil) that only modify genital blood flow, PT-141 acts directly on central neuroendocrine pathways to stimulate sexual desire and arousal, independent of nitric oxide or vasodilation pathways
- FDA-approved (marketed as Vyleesi) for treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women, with robust Phase 3 clinical trial data supporting efficacy
- Minimal off-target peripheral vascular effects, with a well-characterized safety profile in clinical research
Primary Research Applications
- Sexual dysfunction and neuroendocrine regulation of sexual behavior research
- Melanocortin receptor signaling and CNS reward pathway studies
- Investigations of central (non-vascular) mechanisms of sexual arousal and motivation
- Preclinical and clinical studies of hypoactive sexual desire disorder (HSDD) and related sexual dysfunction conditions
Manufactured to ≥98% purity, sterile-filtered, and lyophilized for long-term storage stability.
For laboratory research use only; not intended for human or veterinary administration outside of approved clinical protocols.
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